Radiosensitivity parameters for lethal mutagenesis in Caenorhabditis elegans.

For the first time track structure theory has been applied to radiobiological effects in a living organism. Data for lethal mutagenesis in Caenorhabditis elegans, obtained after irradiation with nine different types of ions of atomic number 1-57 and gamma rays have yielded radiosensitivity parameters (E0, sigma 0, kappa, m = 68 Gy, 2.5 x 10(-9) cm2, 750, 2) comparable with those found for the transformation of C3HT10 1/2 cells (180 Gy, 1.15 x 10(-10) cm2, 750, 2) but remote from those (E0 and sigma 0 = approximately 2 Gy, approximately 5 x 10(-7) cm2) for mammalian cell survival.